PCGame

Genome Guardian

Top-down roguelite shooter with DNA-combined weapons and customizable turrets

Alpherior · Released May 7, 2024

ActionCasualIndieRPG

Reviews
Very Positive
91% of 735
Recent reviews
Not enough recent
Players
2
daily peak, Nov 7, 2026
Steam Deck
Playable
Last update on Steam
1 year ago
Jul 21, 2025
Minimum PC
0.8 GB disk
Full requirements

What is Genome Guardian?

Genome Guardian is a top-down roguelite shooter set in a microscopic world, where you control a turret trying to survive attacks by microbes. Across short runs with different modes and depths, you combine DNA bases into weapons, choose perks and mods, and research permanent upgrades.

For you if...

  • +you like experimenting with weapon combinations and turret builds
  • +you enjoy fast-paced survival combat
  • +you want short runs with new options to unlock

Not for you if...

  • −you prefer long, continuous levels over short runs
  • −you want a shooter with few upgrade decisions

What players say

91% of 735 reviews are positive

Players praise the variety of weapon combinations, turrets, and builds. Common complaints concern repetitive encounters, a cluttered interface, and projectiles that can be hard to tell apart during combat.

Screenshots and trailer

Genome Guardian screenshot 1

Genome Guardian system requirements

Minimum: 0.8 GB of disk space.

As published by the developer.

Can my PC run Genome Guardian?

The published requirements do not name a graphics card we can compare.

Set up my PC →

Minimum

OS
Windows 10
Storage
800 MB available space
Notes
Change Quality / Render Scale in SETTINGS if low FPS

Recommended

OS
Windows 10
Storage
800 MB available space
Notes
Change Quality / Render Scale in SETTINGS if low FPS

Does Genome Guardian have co-op or multiplayer?

No: single-player only, no multiplayer modes declared.

Does Genome Guardian run on Steam Deck?

Playable Playable: it runs on Steam Deck with some adjustments.

  • Sometimes shows mouse, keyboard or non-Deck controller icons
  • Some in-game text is small and may be hard to read
  • All functionality is accessible with the default controller configuration
  • Default graphics settings perform well on Steam Deck

PC version details

DRM
None declared on Steam
Controller
Full controller support
Platforms
Windows
Achievements
100
Steam features
Cloud saves, Family Sharing, Trading cards
Languages
Text only: English.

Does Genome Guardian use AI-generated content?

No AI-generated content is disclosed on the game's Steam page.

Self-reported by the developer under Steam rules: it covers AI content that ships in the game, not tools used to make it. Steam page checked on Oct 25, 2026. How to filter AI games on Steam

Tags

Recent updates

Games like Genome Guardian