Genome Guardian 2

Top-down survival roguelite with modular machines and DNA-based weapon fusion

Alpherior · Released Oct 11, 2026

Reviews: Very Positive; 94% of 523
Recent reviews: Very Positive; 88% of 104 in 30 days
Players: 28; daily peak, Oct 28, 2026
Steam Deck: Playable
Last update on Steam: 4 days ago; Oct 24, 2026
Minimum PC: 4 GB RAM · 1 GB disk; Full requirements

What is Genome Guardian 2?

A top-down roguelite shooter set in a microscopic world. You assemble a biomechanical machine, fight microbes, mine resources, and activate gadgets during twenty-minute runs or an endless mode. Research unlocks permanent upgrades between attempts.

For you if...

+you enjoy adjusting how your machine moves and shoots
+you want runs you can save and resume anytime

Not for you if...

−you want cooperative or competitive multiplayer

What players say

94% of 523 reviews are positive · 88% of 104 in the last 30 days

Players praise the build variety, weapon combinations, and electronic soundtrack. Some criticize the tutorial and weapon advice for being too intrusive.

Screenshots and trailer

Genome Guardian 2 system requirements

Minimum: 4 GB RAM, 1 GB of disk space.

As published by the developer.

Can my PC run Genome Guardian 2?

The published requirements do not name a graphics card we can compare.

Set up my PC →

Minimum

OS: Windows 10
Memory: 4096 MB RAM
Storage: 1000 MB available space

Does Genome Guardian 2 have co-op or multiplayer?

No: single-player only, no multiplayer modes declared.

Single-player

Does Genome Guardian 2 run on Steam Deck?

Playable Playable: it runs on Steam Deck with some adjustments.

Some in-game text is small and may be hard to read
All functionality is accessible with the default controller configuration
Shows Steam Deck controller icons
Default graphics settings perform well on Steam Deck

PC version details

DRM: None declared on Steam
Controller: Full controller support
Platforms: Windows
Achievements: 100
Steam features: Cloud saves, Family Sharing, Trading cards
Languages: Full audio: English, French, Italian, German, Spanish - Spain, Japanese, Korean, Portuguese - Brazil, Russian, Simplified Chinese.

Does Genome Guardian 2 use AI-generated content?

No AI-generated content is disclosed on the game's Steam page.

Self-reported by the developer under Steam rules: it covers AI content that ships in the game, not tools used to make it. Steam page checked on Oct 27, 2026. How to filter AI games on Steam